Background and Purpose: Nowadays, happiness as one of the positive psychology factors is of fundamental importance. Therefore, identifying the
factors affecting this concept would be considerably helpful in the enhancement of well-being. Regarding this, the aim of the current study was to investigate the relationship of psychological well-being and happiness with religious orientation in female students.
      Materials and Methods: This descriptive and correlational study was conducted on 200 students of Islamic Azad University, Arak Branch, who were selected through cluster sampling method in 2014-2015. Data collection was performed using three research instruments including Ryff’s Psychological Well-being Scale, Oxford Happiness Questionnaire, and Allport's Religious Orientation Scale. Data analysis was performed through Pearson product-moment correlation and regression analysis.
      Results: According to the results, there was a significant direct correlation between psychological well-being, happiness, and internal religious orientation
(r=0.325, P<0.05). However, psychological well-being, happiness, and external religious orientation were indirectly correlated (r=0.0137, P<0.05). In addition, a significant positive correlation was observed between happiness and psychological well-being (r=0.263, P<0.05).
     Conclusion: As the findings of the present study indicated, religious orientation and happiness are associated with psychological well-being. Consequently, religion and happiness should be more considered in planning the preventive programs (primary and secondary).