Background and Purpose: The mental health is one of the pillars of health, especially in effective and constructive classes in a society. The essential dynamics, development and promotion of the society are due to mental health. We consider religion as a means that relate us to a higher and eternal power that is God. It can be a very strong psychological support. The purpose of this article is to study the relationship between locus of control and religious believe with mental Health of students in Mazandaran University of Medical Science.

   Materials and Methods: This descriptive- analytic study has done on 300 students of Mazandaran University of Medical Sciences selected randomized- stratified according to population based (population 2,000). GHQ- 28 questionnaires with 28 items in field of Public Health, Temple questionnaire with 65 questions regarding religious beliefs and Rotter Locus of Control questionnaire with 29 questions related to the locus of control, were distributed randomly among students in each class. Data analyzed using SPSS software version 15 and t-test, logistic regression and Pearson correlation were analyzed.

   Results: Total scores of students with external control and internal control indicates that students with external control are suffering from more physical complaints, sleep disorders and more anxiety and lesser social function and they are more susceptible to depression. This difference was statistically significant in all cases.

   Conclusion: Based on the results of this study, whatever the internal control to be more physical complaints, anxiety and sleep disturbances to be less and reduce social functioning and depression in students, so it can be concluded that education and scientific advice to the aspect of internal control can play an important role among students.